Early on, 5 w 30 motor oil was the recommended lubricant, both for the 4-speed Muncie and the 5-speed Isuzu. At some point, and I think that was in 86 that they changed to recommending Synchromesh. I don't know if it came about with the introduction of the Getrag, but it did include the Isuzu, which was identical to the 85 Isuzu.
Lots of people, including myself, have changed the early 4 and 5 speeds to Synchromesh without any problems, and usually with improvement of shifting.
I don't know if the change from 5 w 30 was due to GM wanting to make a few extra bucks by providing something claimed to be necessary for the transmissions at more than twice the cost of readily available motor oil, or because there was something different about the later transmissions. Whatever the case, most of us have found, or think we've found, that the transmission shifting is smoother with Synchromesh.